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[18F]altanserin
- Development stage
- Preclinical
- Lead developer
- Washington University School of Medicine
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[18F]altanserin is a radioligand used in positron emission tomography (PET) imaging for the visualization and quantification of serotonin 2A (5-HT2A) receptors in the brain. It is a fluorine-18 labeled version of altanserin, which is a potent and selective 5-HT2A receptor antagonist with >100-fold selectivity over D2/3 receptors. The compound is administered intravenously as a bolus injection and allows researchers to measure changes in endogenous serotonin levels in the brain.
- Other names
- Fluorine-18 altanserinFluorine18 altanserinFluorine 18 altanserin(18F)AltanserinAltanserin F-18[18F]-AltanserinJP42JP-42JP 42
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)HTR6 (5-hydroxytryptamine receptor 6)
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